Easter Delivery: Order by 2:30pm, 26th March (Standard) or 2:30pm, 31st March (Next Day) to receive your order before the bank holiday.
NAD+ Supplements
Revitalise Your Cellular Energy & Focus
Age-related cellular energy decline is an increasingly common condition caused by the natural reduction of nicotinamide adenine dinucleotide (NAD+) as we get older. This drop in levels frequently presents with symptoms such as chronic fatigue, brain fog, and a slowed metabolism. By proactively supporting your body with over-the-counter liposomal NAD+ supplements or injectable NAD+ therapies, you can effectively manage fatigue, enhance cognitive clarity, and maintain everyday vitality.
More Information
An Overview From Our Clinical Team
"NAD+ supplements are primarily used to support cellular energy production, maintain healthy mitochondrial function, and promote natural DNA repair processes that decline as we age. By replenishing this essential coenzyme, these supplements aim to reduce fatigue, support metabolic health and enhance overall cognitive and physical vitality, offering a proactive approach to age-related wellness rather than a cure for specific diseases."
Boost Your Wellness with Oral NAD+ Supplements
What are NAD+ supplements?
NAD+ supplements are dietary products designed to raise the levels of nicotinamide adenine dinucleotide in your body. They typically contain active NAD+ or precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to support cellular energy and metabolism. If you are looking for an effective NAD supplement in the UK, liposomal oral capsules and liquids are the most common and convenient formats available to you.
| Ingredient Type | What is it? | How it Works | Best For |
|---|---|---|---|
| Direct NAD+ | The fully formed, active coenzyme. | Historically hard to absorb orally, but modern liposomal delivery protects it through the gut for direct cellular uptake. | Enhanced replenishment when used in liposomal or injectable formats. |
| Nicotinamide Riboside (NR) | A highly efficient NAD+ precursor (a form of Vitamin B3). | Easily enters the cell and converts to NMN, which then converts directly into active NAD+. Highly researched for safety. | Long-term daily maintenance and steady cellular energy support. |
| Nicotinamide Mononucleotide (NMN) | The direct precursor step right before NAD+. | One step closer to NAD+ than NR. It is rapidly absorbed and converted into NAD+ within the body's tissues. | Targeted anti-ageing protocols and supporting healthy metabolic function. |
Who can benefit from NAD+ supplements?
Adults experiencing age-related fatigue, reduced mental clarity, or slower physical recovery often benefit most from taking a NAD+ supplement. These products are popular among people over the age of 30 looking to support their metabolic health, maintain muscle function and promote overall longevity safely and effectively.
Scientific Evidence Supporting NAD+ Therapy
Research indicates that replenishing nicotinamide adenine dinucleotide can improve mitochondrial function and support the activation of sirtuins, which are proteins linked to longevity [1]. While human clinical trials are ongoing, early studies demonstrate that oral NAD+ precursors can successfully raise blood NAD+ levels, offering promising NAD supplement benefits for cellular repair and energy [2].
Understanding NAD+ (Nicotinamide Adenine Dinucleotide)
Nicotinamide adenine dinucleotide is a crucial coenzyme found in every living cell of your body. It acts as a metabolic messenger that helps turn the nutrients you eat into usable cellular energy (ATP) while regulating vital biological processes, including DNA maintenance, inflammation responses and healthy circadian rhythms.
Supplementing NAD+ Video Guide
Watch Dr Paul Anderson explain everything you need to know about how to supplement NAD+ naturally, including how quickly your body can process it, how your body is set up to take in NAD supplements and how oral NAD compares to IV NAD.
Is NAD the same as NAD+?
While the terms are often used interchangeably in wellness circles, NAD refers to the general molecule, whereas NAD+ specifically describes its active, oxidised form. Your body uses NAD+ to accept electrons during cellular respiration, making it the critical variant responsible for energy production and supporting your mitochondria.
Why NAD+ Levels Decline With Age
Your natural NAD+ levels decline with age because your body produces less of it while simultaneously consuming more to repair accumulated cellular damage. By the time you reach middle age, your natural reserves can drop by up to 50%, which is why introducing a daily NAD booster into your routine can be highly beneficial [3].
How are oral NAD+ supplements different to injections and patches?
Oral NAD+ supplements offer a convenient, daily way to support your cellular health from home, whereas injections deliver the coenzyme directly into your bloodstream for immediate, high-dose absorption. While injections bypass the digestive system entirely, modern formulations improve oral bioavailability by protecting the molecule as it passes through your gut.
| Delivery Method | Bioavailability (Absorption) | Convenience | Typical Use Case |
|---|---|---|---|
| Standard Oral Capsules (Precursors) | Moderate to Good (relies on digestive system processing) | High (easy to take at home or on the go) | Every day cellular support and maintaining healthy metabolic function over time. |
| Liposomal NAD+ | High (lipid layer protects molecules from stomach acid) | High (available in liquid or protected capsule form) | Maximising oral absorption and ensuring more active ingredients reach the bloodstream. |
| At-home Subcutaneous Injections | Very High (bypasses digestion, gradually absorbed into the bloodstream for sustained release) | High (allows for pharma-grade supplement at home, but requires a self-injection) | Consistent, high-dose replenishment managed from home without the need for frequent clinic visits. |
| IV Therapy | Maximum (bypasses digestion entirely, 100% immediate absorption) | Low (requires a clinic visit and medical supervision) | Immediate, high-dose replenishment for acute fatigue or clinical recovery protocols. |
How do NAD+ supplements work in the body?
NAD+ supplements work by providing your cells with the raw materials needed to synthesise this vital coenzyme, or by supplying it directly. Once absorbed, the active ingredients enter your cellular salvage pathway. Here, they help convert food into adenosine triphosphate (ATP), the primary energy currency of your cells.
This biological process does more than just power muscle contractions and brain function. It also provides the necessary fuel for enzymes that repair damaged DNA and reduce oxidative stress, leading to the widely discussed NAD+ supplement benefits for long-term health and vitality [4].
Lifestyle Tips to Naturally Support NAD+ Levels
While taking a dedicated NAD booster is highly effective, you can also support your body's natural production through targeted lifestyle choices [5]. Positive lifestyle choices include:
- Dietary Adjustments: Eat foods rich in vitamin B3, such as poultry, oily fish, mushrooms and avocados.
- Regular Exercise: Engage in consistent cardiovascular and resistance training to stimulate mitochondrial function.
- Intermittent Fasting: Practice safe fasting periods, which have been shown to encourage natural NAD+ synthesis.
- Quality Sleep: Prioritise seven to nine hours of restorative sleep to maintain your circadian rhythm.
- Sun Protection: Minimise excessive UV exposure, as repairing sun-damaged skin consumes large amounts of your cellular energy reserves.
How to Use NAD+ Supplements Safely
Taking Oral NAD+ at Home
You should take oral NAD+ capsules with a glass of water on an empty stomach, ideally in the morning, to align with your body's natural circadian rhythm and energy needs. Always follow the specific dosage instructions provided on the product packaging or directed by your healthcare provider.
Common Reactions and What to Expect
When you first start taking a NAD+ supplement, you might experience mild digestive changes, such as slight bloating or a mild flushing sensation. These effects are usually temporary and ease rapidly as your body adjusts to the increased cellular activity.
How often should you take NAD+ supplements?
For optimal results, you should take your chosen NAD+ supplement daily, depending on the specific usage instructions of the product you are using. Consistency is key because your body continuously uses nicotinamide adenine dinucleotide for metabolic processes and DNA repair, meaning regular replenishment is required to maintain elevated levels over time.
Best Practices for Storing and Using Oral NAD+ Supplements
Store your supplements in their original packaging in a cool, dry place away from direct sunlight to preserve their potency. If you are using a liposomal NAD product, check the label carefully, as some liquid formulations may require refrigeration after opening to maintain their stability and effectiveness.
When to Seek Medical Advice
You should consult a doctor if you experience persistent gastrointestinal discomfort, severe headaches, or any signs of an allergic reaction after taking the supplement. It is also important to seek advice before starting if you have pre-existing liver conditions, diabetes, or kidney disease.
Side Effects: Are NAD+ supplements safe?
Possible Side Effects and How to Manage Them
NAD supplements are generally safe and well-tolerated by healthy adults, with the most common side effects being mild nausea, loose stools, or headaches [6]. You can often manage these minor symptoms by taking the supplement alongside a meal or temporarily reducing your daily dose.
Who should avoid NAD+ supplements?
Pregnant or breastfeeding women, children and people with active liver/kidney disease should avoid these supplements unless explicitly advised by a medical professional. If you are undergoing treatments that suppress your immune system, you must consult your doctor first before starting a regimen.
Does NAD+ cause cancer?
There is no clinical evidence to suggest that taking a NAD booster supplement causes cancer in healthy individuals. However, because the coenzyme promotes cellular growth and energy, individuals with an active cancer diagnosis should avoid supplementation, as it could theoretically support tumour metabolism [7]. Individuals with a history of cancer should consult their healthcare providers before starting NAD+ supplements.
Combining NAD+ With Other Wellness Supplements
You can safely combine oral NAD with other wellness products like resveratrol, vitamins and omega-3 fatty acids to enhance your overall health routine. In fact, combining it with sirtuin activators is a popular strategy to maximise the efficacy of the best NAD+ supplements available.
Does NAD+ interact with medications?
Yes, these supplements can interact with certain medications, including blood pressure drugs, diabetes medications, and anticoagulants. High doses may alter your blood sugar levels or blood pressure, so you must speak with a pharmacist or GP if you currently take prescription medicines.
NAD+ Supplements FAQs
Is taking NAD orally effective?
Yes, taking oral NAD+ is effective. While older forms of the molecule struggled to survive the digestive tract, modern delivery methods, including advanced capsule technology and liposomal NAD+, help NAD+ or its precursors reach the bloodstream to support the body's natural production or levels of NAD+.
What are the benefits of liposomal NAD+?
Liposomal NAD+ benefits stem from the way the supplement is encapsulated in tiny lipid (fat) bubbles. This protects the delicate molecule from stomach acid, resulting in much higher absorption rates compared to traditional powders, ensuring you get the most out of your supplement.
What are the best NAD+ supplements in the UK?
The best NAD supplements available to UK customers are those manufactured in GMP-certified facilities with clear, transparent ingredient lists. Products like Vivere's NAD+ capsules and the CellRegen range, all available through UK Meds, are highly rated because they combine NAD+ with targeted vitamins and plant extracts for maximum absorption.
How long does it take to see results?
While some people notice a subtle energy boost within the first few days of taking an oral NAD+ supplement, it typically takes two to four weeks of consistent daily use to experience the full benefits, such as improved mental clarity and physical stamina.
Sources and Clinical Research
- [1] Therapeutic potential of NAD-boosting molecules: the in vivo evidence.
- [2] Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial.
- [3] NAD+ metabolism and its roles in cellular processes during ageing.
- [4] NAD⁺ in aging, metabolism, and neurodegeneration.
- [5] NAD+ homeostasis in health and disease.
- [6] Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.
- [7] NAD+ metabolism, stemness, the immune response, and cancer.
Medication delivered the next day from UK pharmacies
Choose the right treatment
From the comfort of your own home or out on the go, choose the treatment you require from our extensive range.
Complete an online consultation
A vital part of our process, your online consultation will be similar questions to that of a GP. Quick and easy, we guarantee privacy and confidentiality.
Delivered discreetly
One of over 100 of our partner regulated UK pharmacies will dispense and ship the treatment to you in discreet packaging.
Rated out of 5 on 
Brilliant
Simple and discrete online consultation process with multiple choices of pack size and tablet strength offered. Received delivery within 3 days (standard delivery) although other options are available
Easy to use and good communication.
Excellent as always
Rated 4.6 out of 5 based on 6958 reviews
Here to help you
Our Customer Service is available Monday to Friday 9am - 5pm. If you need urgent assistance, do not use this service. Call 111, or in an emergency call 999. Visit our help section
