How Mounjaro works in weight management and diabetes – explaining dual-action effects on GLP-1 and GIP receptors

Mounjaro, also known as tirzepatide, is a groundbreaking treatment approved by the MHRA for type 2 diabetes and weight management [1]. What sets it apart is its dual-action effect on two key hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). This dual-targeting mechanism helps regulate blood sugar levels, reduce appetite and support weight loss. Here’s a closer look at how Mounjaro works to achieve these benefits. This information is for educational purposes and not a substitute for advice from a healthcare provider.

Key Takeaways

What is Mounjaro?

Mounjaro (tirzepatide) is a medicine approved for managing type 2 diabetes and supporting weight loss. It works by targeting two hormones, GLP-1 and GIP, to control blood sugar, reduce hunger, and help with weight loss.

How Does Mounjaro Work?

• For diabetes: It increases insulin, reduces sugar release by the liver, and improves how the body uses insulin, leading to better blood sugar control.

• For weight loss: It reduces appetite, slows digestion, and helps people feel full longer, naturally lowering calorie intake.

Why is Mounjaro Unique?

Unlike other treatments that only target GLP-1, Mounjaro works on both GLP-1 and GIP, making it more effective for blood sugar management and weight loss. It’s suitable for adults with type 2 diabetes or weight-related health conditions, but a doctor’s consultation is necessary to determine if it’s right for you.

What are GLP-1 and GIP receptors?

GLP-1 and GIP are natural hormones in the body that play an important role in managing blood sugar and appetite:

• GLP-1: Helps the body produce insulin, slows digestion, and reduces hunger. [2]

• GIP: Enhances insulin release and works alongside GLP-1 to support blood sugar control and metabolism.

Mounjaro activates both GLP-1 and GIP receptors, amplifying the effects of these hormones to improve health outcomes.

How does Mounjaro work for diabetes management?

Mounjaro helps control blood sugar levels by:

• Increasing insulin production: It stimulates the pancreas to produce more insulin when blood sugar levels are high.

• Reducing sugar release: It signals the liver to release less glucose into the bloodstream.

• Improving insulin sensitivity: It helps the body use insulin more effectively, reducing overall blood sugar levels.

These effects make Mounjaro highly effective for managing type 2 diabetes, often improving HbA1c levels (a key marker of blood sugar control).

How does Mounjaro support weight management?

Mounjaro’s effects on GLP-1 and GIP receptors also make it a powerful tool for weight loss:

• Suppressing appetite: By acting on the brain’s hunger centres, Mounjaro helps reduce cravings and makes it easier to eat less.

• Slowing digestion: It slows how quickly food leaves the stomach, which helps people feel full for longer after eating.

• Reducing calorie intake: These combined effects naturally lead to lower calorie consumption, supporting gradual and sustainable weight loss when combined with healthier lifestyle choices.

Why is the dual-action mechanism unique?

Most diabetes or weight loss medications focus solely on GLP-1. Mounjaro’s ability to target both GLP-1 and GIP receptors sets it apart, making it more effective for some people. The dual-action mechanism provides enhanced appetite control, improved blood sugar management, and greater weight loss compared to GLP-1 medications alone.

How long does it take to see results?

Many people start noticing improvements in blood sugar control within weeks of starting Mounjaro. Weight loss results may take a bit longer, typically becoming noticeable after 1-2 months of consistent use. Your healthcare provider can provide more specific guidance based on your individual goals and health conditions.

Who can benefit from Mounjaro?

Mounjaro is suitable for adults with:

• Type 2 diabetes: Especially those who have not achieved adequate control with other treatments.

• Weight-related health conditions: Those with obesity or high BMI may benefit from appetite suppression and weight loss.

It’s important to speak with a healthcare provider to determine if Mounjaro is right for you.

Final thoughts

Mounjaro works by targeting both GLP-1 and GIP receptors, making it an innovative solution for managing type 2 diabetes and supporting weight loss. Its dual-action mechanism improves blood sugar control, suppresses appetite and promotes sustainable weight loss. If you’re considering Mounjaro, consult your doctor to discuss how it could help you achieve your health goals.

Beginner’s Guide to Mounjaro for Weight Loss

Discover everything you need to know about Mounjaro for weight loss in our beginner's guide. This in-depth guide explains how Mounjaro (Tirzepatide) works, whether it’s approved by the MHRA, who it’s suitable for, and much more. Learn how Mounjaro supports weight management and how it compares to other treatments like Wegovy. If you’re considering options to aid your weight loss journey, this guide provides expert insights to help you decide. Please note, all requests for Mounjaro supply are subject to an online clinical consultation and approval by a registered independent prescriber.

Disclaimer: This guide is for informational purposes only. Always consult a medical professional before starting any new medication.

References

[1] Four-dose Mounjaro “KwikPen” approved by MHRA for diabetes and weight management

[2] GLP-1 agonists | Diabetes UK