Can Semaglutide Injections Cause Hair Loss: The Possibility of Balding When Taking Ozempic and Wegovy

Semaglutide, a medication used in Ozempic and Wegovy, has become increasingly popular for managing type 2 diabetes and supporting weight loss. However, some patients have raised concerns about whether the treatment may lead to hair loss or thinning. This article explores whether semaglutide can cause hair loss, whether it affects men and women differently, how it compares with tirzepatide, and what you can do if you experience hair changes while on treatment.

Key Takeaways

Here are the five biggest takeaways from this article about semaglutide injections and hair loss:

• Hair loss has been reported by some people taking semaglutide, though it is not one of the most common side effects.

• The official patient information for Wegovy lists hair loss as a possible side effect, particularly in those who experience significant weight loss.

• Evidence suggests that women may have a slightly higher risk of experiencing hair loss compared to men when using semaglutide.

• Both semaglutide and tirzepatide users have reported hair loss, though studies suggest rates are similar between the two medicines.

• Maintaining a balanced diet, avoiding extreme calorie restriction, and managing stress may help reduce the risk of hair thinning while on semaglutide.

Does Semaglutide Cause Hair Loss?

Research shows that some patients taking semaglutide do experience hair loss. A published case highlighted an individual developing hair thinning after significant weight loss linked to semaglutide treatment [1]. While this does not mean the medicine directly damages hair follicles, it does suggest an association, particularly in cases of rapid weight reduction.

Is hair loss listed as an official side effect of Semaglutide?

Yes. According to the official Wegovy patient information leaflet, hair loss has been observed, especially in those who lost more than 20% of their body weight [2]. This suggests that while hair loss is not guaranteed, it is recognised as a possible side effect in certain individuals.

Does Semaglutide cause hair loss in females?

A large study indicated that women taking semaglutide had a higher likelihood of reporting hair loss compared with men [3]. This difference may be due to hormonal changes, variations in hair growth cycles, or differences in nutritional status during weight loss.

Hair Loss: Semaglutide vs Tirzepatide

Tirzepatide, available under the brand name Mounjaro, has also been linked to hair loss in some patients. A study comparing semaglutide and tirzepatide found that both medicines were associated with hair changes, though the overall risk appeared similar [4].

The Mounjaro patient leaflet also acknowledges hair loss as a possible side effect, particularly in participants from weight management trials [5]. This suggests that hair loss may not be unique to semaglutide but instead related to weight loss mechanisms in general.

Why might you experience hair loss when taking Semaglutide?

There are several reasons why someone might notice hair loss while using semaglutide:

Rapid weight loss

When the body undergoes fast weight reduction, it may trigger temporary hair shedding, a condition known as telogen effluvium. This happens when the body reallocates energy away from hair growth to support more vital functions.

Nutritional deficiencies

Losing weight quickly can sometimes result in low levels of essential nutrients, such as iron, zinc, vitamin D and protein. All of these are important for healthy hair growth. If the diet is not balanced, hair thinning may become more noticeable.

Hormonal and metabolic changes

Weight loss and the use of GLP-1 receptor agonists like semaglutide can influence hormones and metabolism. These changes may alter the hair growth cycle, leading to more shedding.

Stress on the body

Adjusting to a new medication, dealing with weight changes, and experiencing lifestyle stress can all impact hair health. Stress is a well-known trigger for hair loss.

How to stop hair loss on Semaglutide

While it may not always be possible to prevent hair shedding entirely, there are steps you can take to reduce the risk:

Eat a balanced diet

Ensure your meals include enough protein, iron-rich foods, healthy fats and a variety of vitamins and minerals. This supports both overall health and strong hair.

Consider supplements

If you are unable to meet nutritional needs through food alone, a multivitamin or specific supplements such as biotin or vitamin D may help. Speak to a healthcare professional before starting any supplements.

Avoid extreme calorie restriction

While semaglutide helps reduce appetite, avoiding overly strict calorie cutting is important. Severe calorie restriction can deprive the body of essential nutrients and worsen hair thinning.

Manage stress

Incorporating relaxation techniques such as walking, meditation, or yoga can help reduce stress levels. Supporting mental well-being can have a positive effect on hair health.

Check for underlying conditions

Hair loss may sometimes be due to other factors, such as thyroid disease or iron deficiency anaemia. If you notice persistent shedding, it may be worth discussing with your GP to rule out underlying conditions.

Final Thoughts

Hair loss is a possible side effect of semaglutide treatment, particularly in those who lose a significant amount of weight. Both men and women can be affected, though studies suggest women may be at slightly higher risk. Tirzepatide, another weight management injection, has also been linked to hair thinning, which suggests that the process of weight loss itself may play a key role. Supporting your body with a balanced diet, managing stress, and seeking medical advice when necessary can help mitigate the effects of hair changes associated with semaglutide.

Sources

[1] Alopecia areata following semaglutide treatment for weight loss: A case report - PMC

[2] Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (emc) | 13799

[3] Risk of Hair Loss with Semaglutide for Weight Loss | medRxiv

[4] Exploring the hair loss risk in glucagon‐like peptide‐1 agonists: Emerging concerns and clinical implications - Buontempo - 2025 - Journal of the European Academy of Dermatology and Venereology - Wiley Online Library

[5] Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (emc) | 15481