Why am I not losing weight on Saxenda?

If you've been prescribed Saxenda and are not seeing the weight loss results you expected, you're not alone. This article aims to answer some of the most frequently asked questions about using Saxenda for weight loss. We will explore how Saxenda works, the usual timeline for results and the importance of maintaining a healthy diet and lifestyle. We'll also discuss whether a calorie deficit is necessary and what to do if you're experiencing side effects. It is important to remember that results take time when using Saxenda. You should persevere with your treatment and consult with your doctor regularly for advice. 

Key Takeaways

Here are the 5 biggest takeaways from this article.

• Weight loss with Saxenda takes time. Significant results typically occur after about 8 weeks of treatment. 

• Saxenda works by mimicking a hormone called GLP-1, which regulates appetite and slows stomach emptying. This helps to reduce feelings of hunger and lowers calorie intake.

• Combining Saxenda with a long-term, reduced-calorie diet and regular exercise enhances weight loss results.

• To lose weight effectively with Saxenda, it's necessary to maintain a calorie deficit.

• Saxenda should only be taken as prescribed by your doctor.

How does Saxenda work?

Saxenda is a prescription medication used to help people lose weight. It contains the active ingredient liraglutide, which mimics a hormone in your body called GLP-1 (glucagon-like peptide-1). According to the Saxenda website, this hormone is naturally released when you eat and helps to regulate your appetite by signalling to your brain that you are full. This action helps to reduce feelings of hunger which leads to lower calorie intake needed for achieving weight loss. Saxenda also slows the emptying of your stomach which helps you to feel fuller for longer after you have eaten.

How long will it take before I lose weight on Saxenda (liraglutide)?

When starting treatment with Saxenda, some people begin to lose weight within the first 2 to 4 weeks. Clinical studies have shown that significant weight loss of at least 5% of total body weight is typically seen after 8 weeks of treatment. On average, adults who use Saxenda for one year can expect to lose around 9.5 kg (1.5 stone), however, individual results may vary and other factors may influence weight loss positively or negatively (Anderson, 2022).

Can diet and lifestyle changes help me to maximise weight loss on Saxenda?

Yes, diet and lifestyle changes are crucial to maximising weight loss when using Saxenda. For the best results, Saxenda should be combined with a long-term, reduced-calorie diet and regular physical activity.

Healthy diet

Prioritising healthy foods not only supports weight loss but also enhances your overall health. Studies on weight loss with liraglutide, as well as other GLP-1 medications like semaglutide and tirzepatide consistently back up eating a healthy diet alongside these treatments (Migala & Cardel, 2024).

Getting active 

Exercise can significantly help you maximise weight loss while using Saxenda. Although not everyone loses weight with Saxenda alone, studies show that combining the medication with an exercise plan leads to more effective results (Anderson, 2022).

Improving sleep quality & reducing stress 

Sleep can significantly enhance your weight loss while using Saxenda. Adequate sleep is crucial for overall well-being and can directly impact your weight loss. Studies indicate that insufficient sleep can disrupt the hormones that regulate appetite, leading to increased hunger and a higher likelihood of overeating (Petrie, 2023).

Do I need to be in a calorie deficit to lose weight with Saxenda?

Yes, being in a calorie deficit is essential for losing weight with Saxenda. Weight loss occurs when you consume fewer calories than your body burns, creating a calorie deficit. Saxenda can help you manage your appetite and reduce your calorie intake, making it easier to achieve this deficit (Saxenda, 2023).

Can a weight loss plateau stop me from losing weight when taking Saxenda?

Yes, experiencing a weight loss plateau can be a common challenge when taking Saxenda. A plateau occurs when your weight loss slows down or stops, despite following your prescribed plan. This can happen because your body adapts to the lower calorie intake and changes in your metabolism over time. A plateau is part of a regular Saxenda weight loss cycle. You should persevere through this time and consult with your healthcare provider if you have any concerns. 

Can the dose strength of Saxenda that I am taking affect how hungry I feel?

Yes, the dose strength of Saxenda can influence how hungry you feel. Saxenda works by mimicking a hormone that regulates appetite, helping you feel fuller for longer and reducing hunger. As your dose is gradually increased during the first few weeks of treatment, you may notice a further reduction in your appetite. It is important to always follow the dosage instructions provided to you by your healthcare provider. You should never adjust your dosage without consulting a doctor. 

Can an underlying health condition stop me from losing weight when I use Saxenda?

Using Saxenda (liraglutide) for weight management can be affected by underlying health conditions. If you suffer from certain conditions then you may not be able to use Saxenda for weight loss. Saxenda is not recommended for patients with severe heart failure as its safety and efficacy have not been tested. Conditions like pancreatitis, thyroid disease, and issues related to heart rate and dehydration may also affect your results when using Saxenda or may prevent you from being able to use it entirely (EMC). 

Should I only take Saxenda as prescribed by my doctor to improve my weight loss results?

Yes, it is essential to follow your doctor's instructions precisely when taking Saxenda to achieve the best weight loss outcomes and to remain safe. Saxenda is a prescription medication that should be used according to specific guidelines tailored to your individual needs and goals. Your doctor will determine the appropriate dose of Saxenda for you based on factors such as your current health, medical history and response to treatment. It is important not to adjust your dosage or stop taking Saxenda without consulting your doctor first. 

Medically Reviewed by:
Dr. Alexis Missick MBChB. MRCGP
GMC reference no: 7151419
LinkedIn
Website

Sources

Saxenda Weight Loss Cycle: Stages of Saxenda Usage

Exploring the Role of Saxenda in Weight Loss & Diabetes

Your Questions About Saxenda Answered

Appetite Suppressants: Can They Really Aid Weight Loss? | UK Meds

How to Lose Weight: Simple Tips For Your Weight Loss Journey | UK Meds

Frequently Asked Questions | Saxenda® (liraglutide) injection 3mg

Dosing Schedule for Saxenda® | Saxenda® (liraglutide) injection 3mg

Stay on Track | Saxenda®